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Zbog sličnosti oksidativnih procesa, diazepam kompetitivno inhibira metabolizam ketamina. Premedikacija sa diazepamom dovodi do produženog poluvremena eliminacije ketamina, što za rezultat ima njegovo pojačano dejstvo. Pojačana sedacija.Po prestanku terapije može se javiti prolazni sindrom u okviru koga se vraćaju simptomi koji su bili razlo
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